Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease: An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region
Identifieur interne : 006972 ( Main/Exploration ); précédent : 006971; suivant : 006973Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease: An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region
Auteurs : Rachel R. Huxley [Australie, États-Unis] ; Federica Barzi [Australie] ; TAI HING LAM [Hong Kong] ; Sebastien Czernichow [Australie, France] ; XIANGHUA FANG [République populaire de Chine] ; Tim Welborn [Australie] ; Jonathan Shaw [Australie] ; Hirotsugu Ueshima [Japon] ; Paul Zimmet [Australie] ; Sun Ha Jee [Corée du Sud] ; Jeetesh V. Patel [Royaume-Uni] ; Ian Caterson [Australie] ; Vlado Perkovic [Australie] ; Mark Woodward [Australie, États-Unis]Source :
- Circulation : (New York, N.Y.) [ 0009-7322 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background-Previous studies have suggested that there is a novel dyslipidemic profile consisting of isolated low high-density lipoprotein cholesterol (HDL-C) level that is associated with increased risk of coronary heart disease, and that this trait may be especially prevalent in Asian populations. Methods and Results-Individual participant data from 220 060 participants (87% Asian) in 37 studies from the Asia-Pacific region were included. Low HDL-C (HDL <1.03 mmol/L in men and < 1.30 mmol/L in women) was seen among 33.1% (95% confidence interval [CI], 32.9-33.3) of Asians versus 27.0% (95% CI, 26.5-27.5) of non-Asians (P<0.001). The prevalence of low HDL-C in the absence of other lipid abnormalities (isolated low HDL-C) was higher in Asians compared with non-Asians: 22.4% (95% CI, 22.2-22.5) versus 14.5% (95% CI, 14.1-14.9), respectively (P<0.001). During 6.8 years of follow-up, there were 574 coronary heart disease and 739 stroke events. There was an inverse relationship between low HDL-C with coronary heart disease in all individuals (hazard ratio, 1.57; 95% CI, 1.31-1.87). In Asians, isolated low levels of HDL-C were as strongly associated with coronary heart disease risk as low levels of HDL-C combined with other lipid abnormalities (hazard ratio, 1.67 [95% CI, 1.27-2.19] versus 1.63 [95% CI, 1.24-2.15], respectively). There was no association between low HDL-C and stroke risk in this population (hazard ratio, 0.95 [95% CI, 0.78 to 1.17] with nonisolated low HDL-C and 0.81 [95% CI, 0.67-1.00] with isolated low HDL-C). Conclusion-Isolated low HDL-C is a novel lipid phenotype that appears to be more prevalent among Asian populations, in whom it is associated with increased coronary risk. Further investigation into this type of dyslipidemia is warranted.
Affiliations:
- Australie, Corée du Sud, France, Hong Kong, Japon, Royaume-Uni, République populaire de Chine, États-Unis
- Nouvelle-Galles du Sud, Région capitale de Séoul, Île-de-France
- Boulogne-Billancourt, Pékin, Sydney, Séoul
- Université de Sydney
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Huxley</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Epidemiology and Community Health, University of Minnesota</s1><s2>Minneapolis</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Barzi, Federica" sort="Barzi, Federica" uniqKey="Barzi F" first="Federica" last="Barzi">Federica Barzi</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Tai Hing Lam" sort="Tai Hing Lam" uniqKey="Tai Hing Lam" last="Tai Hing Lam">TAI HING LAM</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University of Hong Kong, School of Public Health/Department of Community Medicine</s1><s3>HKG</s3><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>University of Hong Kong, School of Public Health/Department of Community Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sebastien" last="Czernichow">Sebastien Czernichow</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Nutrition, Ambroise Pare Hospital and University of Versailles Saint Quentin en Yvelines</s1><s2>Boulogne-Billancourt</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Boulogne-Billancourt</settlement></placeName></affiliation></author><author><name sortKey="Xianghua Fang" sort="Xianghua Fang" uniqKey="Xianghua Fang" last="Xianghua Fang">XIANGHUA FANG</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Epidemiology and Social Medicine, Xuanwu Hospital, Capital Medical University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Welborn, Tim" sort="Welborn, Tim" uniqKey="Welborn T" first="Tim" last="Welborn">Tim Welborn</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital</s1><s2>Nedlands</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Nedlands</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Jonathan" sort="Shaw, Jonathan" uniqKey="Shaw J" first="Jonathan" last="Shaw">Jonathan Shaw</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Baker IDI Heart and Diabetes Institute</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker IDI Heart and Diabetes Institute</wicri:noRegion></affiliation></author><author><name sortKey="Ueshima, Hirotsugu" sort="Ueshima, Hirotsugu" uniqKey="Ueshima H" first="Hirotsugu" last="Ueshima">Hirotsugu Ueshima</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Health Science, Shiga University of Medical Science</s1><s2>Shiga</s2><s3>JPN</s3><sZ>8 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Zimmet, Paul" sort="Zimmet, Paul" uniqKey="Zimmet P" first="Paul" last="Zimmet">Paul Zimmet</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Baker IDI Heart and Diabetes Institute</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker IDI Heart and Diabetes Institute</wicri:noRegion></affiliation></author><author><name sortKey="Ha Jee, Sun" sort="Ha Jee, Sun" uniqKey="Ha Jee S" first="Sun" last="Ha Jee">Sun Ha Jee</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institute for Health Promotion, Graduate School of Public Health, Yonsei University</s1><s2>Seoul</s2><s3>KOR</s3><sZ>10 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Patel, Jeetesh V" sort="Patel, Jeetesh V" uniqKey="Patel J" first="Jeetesh V." last="Patel">Jeetesh V. Patel</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Sandwell Medical Research Unit, Sandwell and West Birmingham Hospitals NHS Trust</s1><s2>West Bromwich</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>West Bromwich</wicri:noRegion></affiliation></author><author><name sortKey="Caterson, Ian" sort="Caterson, Ian" uniqKey="Caterson I" first="Ian" last="Caterson">Ian Caterson</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Boden Institute, Sydney Medical School, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Epidemiology, Johns Hopkins University</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0016810</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 12-0016810 INIST</idno><idno type="RBID">Pascal:12-0016810</idno><idno type="wicri:Area/PascalFrancis/Corpus">001738</idno><idno type="wicri:Area/PascalFrancis/Curation">004771</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001955</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001955</idno><idno type="wicri:doubleKey">0009-7322:2011:Huxley R:isolated:low:levels</idno><idno type="wicri:Area/Main/Merge">006E06</idno><idno type="wicri:Area/Main/Curation">006972</idno><idno type="wicri:Area/Main/Exploration">006972</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease: An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region</title><author><name sortKey="Huxley, Rachel R" sort="Huxley, Rachel R" uniqKey="Huxley R" first="Rachel R." last="Huxley">Rachel R. Huxley</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Epidemiology and Community Health, University of Minnesota</s1><s2>Minneapolis</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Barzi, Federica" sort="Barzi, Federica" uniqKey="Barzi F" first="Federica" last="Barzi">Federica Barzi</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Tai Hing Lam" sort="Tai Hing Lam" uniqKey="Tai Hing Lam" last="Tai Hing Lam">TAI HING LAM</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University of Hong Kong, School of Public Health/Department of Community Medicine</s1><s3>HKG</s3><sZ>3 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>University of Hong Kong, School of Public Health/Department of Community Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sebastien" last="Czernichow">Sebastien Czernichow</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Nutrition, Ambroise Pare Hospital and University of Versailles Saint Quentin en Yvelines</s1><s2>Boulogne-Billancourt</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Boulogne-Billancourt</settlement></placeName></affiliation></author><author><name sortKey="Xianghua Fang" sort="Xianghua Fang" uniqKey="Xianghua Fang" last="Xianghua Fang">XIANGHUA FANG</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Epidemiology and Social Medicine, Xuanwu Hospital, Capital Medical University</s1><s2>Beijing</s2><s3>CHN</s3><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Welborn, Tim" sort="Welborn, Tim" uniqKey="Welborn T" first="Tim" last="Welborn">Tim Welborn</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital</s1><s2>Nedlands</s2><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Nedlands</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Jonathan" sort="Shaw, Jonathan" uniqKey="Shaw J" first="Jonathan" last="Shaw">Jonathan Shaw</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Baker IDI Heart and Diabetes Institute</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker IDI Heart and Diabetes Institute</wicri:noRegion></affiliation></author><author><name sortKey="Ueshima, Hirotsugu" sort="Ueshima, Hirotsugu" uniqKey="Ueshima H" first="Hirotsugu" last="Ueshima">Hirotsugu Ueshima</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Health Science, Shiga University of Medical Science</s1><s2>Shiga</s2><s3>JPN</s3><sZ>8 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Zimmet, Paul" sort="Zimmet, Paul" uniqKey="Zimmet P" first="Paul" last="Zimmet">Paul Zimmet</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Baker IDI Heart and Diabetes Institute</s1><s2>Melbourne, Victoria</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker IDI Heart and Diabetes Institute</wicri:noRegion></affiliation></author><author><name sortKey="Ha Jee, Sun" sort="Ha Jee, Sun" uniqKey="Ha Jee S" first="Sun" last="Ha Jee">Sun Ha Jee</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institute for Health Promotion, Graduate School of Public Health, Yonsei University</s1><s2>Seoul</s2><s3>KOR</s3><sZ>10 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Patel, Jeetesh V" sort="Patel, Jeetesh V" uniqKey="Patel J" first="Jeetesh V." last="Patel">Jeetesh V. Patel</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Sandwell Medical Research Unit, Sandwell and West Birmingham Hospitals NHS Trust</s1><s2>West Bromwich</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>West Bromwich</wicri:noRegion></affiliation></author><author><name sortKey="Caterson, Ian" sort="Caterson, Ian" uniqKey="Caterson I" first="Ian" last="Caterson">Ian Caterson</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Boden Institute, Sydney Medical School, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Epidemiology, Johns Hopkins University</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Circulation : (New York, N.Y.)</title><title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title><idno type="ISSN">0009-7322</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Circulation : (New York, N.Y.)</title><title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title><idno type="ISSN">0009-7322</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asia</term><term>Cardiovascular disease</term><term>Cholesterol</term><term>Coronary heart disease</term><term>Epidemiology</term><term>Lipoprotein</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie coronaire</term><term>Lipoprotéine</term><term>Cholestérol</term><term>Facteur risque</term><term>Asie</term><term>Pathologie de l'appareil circulatoire</term><term>Epidémiologie</term><term>Maladie cardiovasculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background-Previous studies have suggested that there is a novel dyslipidemic profile consisting of isolated low high-density lipoprotein cholesterol (HDL-C) level that is associated with increased risk of coronary heart disease, and that this trait may be especially prevalent in Asian populations. Methods and Results-Individual participant data from 220 060 participants (87% Asian) in 37 studies from the Asia-Pacific region were included. Low HDL-C (HDL <1.03 mmol/L in men and < 1.30 mmol/L in women) was seen among 33.1% (95% confidence interval [CI], 32.9-33.3) of Asians versus 27.0% (95% CI, 26.5-27.5) of non-Asians (P<0.001). The prevalence of low HDL-C in the absence of other lipid abnormalities (isolated low HDL-C) was higher in Asians compared with non-Asians: 22.4% (95% CI, 22.2-22.5) versus 14.5% (95% CI, 14.1-14.9), respectively (P<0.001). During 6.8 years of follow-up, there were 574 coronary heart disease and 739 stroke events. There was an inverse relationship between low HDL-C with coronary heart disease in all individuals (hazard ratio, 1.57; 95% CI, 1.31-1.87). In Asians, isolated low levels of HDL-C were as strongly associated with coronary heart disease risk as low levels of HDL-C combined with other lipid abnormalities (hazard ratio, 1.67 [95% CI, 1.27-2.19] versus 1.63 [95% CI, 1.24-2.15], respectively). There was no association between low HDL-C and stroke risk in this population (hazard ratio, 0.95 [95% CI, 0.78 to 1.17] with nonisolated low HDL-C and 0.81 [95% CI, 0.67-1.00] with isolated low HDL-C). Conclusion-Isolated low HDL-C is a novel lipid phenotype that appears to be more prevalent among Asian populations, in whom it is associated with increased coronary risk. Further investigation into this type of dyslipidemia is warranted.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Corée du Sud</li><li>France</li><li>Hong Kong</li><li>Japon</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Nouvelle-Galles du Sud</li><li>Région capitale de Séoul</li><li>Île-de-France</li></region><settlement><li>Boulogne-Billancourt</li><li>Pékin</li><li>Sydney</li><li>Séoul</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Huxley, Rachel R" sort="Huxley, Rachel R" uniqKey="Huxley R" first="Rachel R." last="Huxley">Rachel R. Huxley</name></region><name sortKey="Barzi, Federica" sort="Barzi, Federica" uniqKey="Barzi F" first="Federica" last="Barzi">Federica Barzi</name><name sortKey="Caterson, Ian" sort="Caterson, Ian" uniqKey="Caterson I" first="Ian" last="Caterson">Ian Caterson</name><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sebastien" last="Czernichow">Sebastien Czernichow</name><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name><name sortKey="Shaw, Jonathan" sort="Shaw, Jonathan" uniqKey="Shaw J" first="Jonathan" last="Shaw">Jonathan Shaw</name><name sortKey="Welborn, Tim" sort="Welborn, Tim" uniqKey="Welborn T" first="Tim" last="Welborn">Tim Welborn</name><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><name sortKey="Zimmet, Paul" sort="Zimmet, Paul" uniqKey="Zimmet P" first="Paul" last="Zimmet">Paul Zimmet</name></country><country name="États-Unis"><noRegion><name sortKey="Huxley, Rachel R" sort="Huxley, Rachel R" uniqKey="Huxley R" first="Rachel R." last="Huxley">Rachel R. Huxley</name></noRegion><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></country><country name="Hong Kong"><noRegion><name sortKey="Tai Hing Lam" sort="Tai Hing Lam" uniqKey="Tai Hing Lam" last="Tai Hing Lam">TAI HING LAM</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Czernichow, Sebastien" sort="Czernichow, Sebastien" uniqKey="Czernichow S" first="Sebastien" last="Czernichow">Sebastien Czernichow</name></region></country><country name="République populaire de Chine"><noRegion><name sortKey="Xianghua Fang" sort="Xianghua Fang" uniqKey="Xianghua Fang" last="Xianghua Fang">XIANGHUA FANG</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Ueshima, Hirotsugu" sort="Ueshima, Hirotsugu" uniqKey="Ueshima H" first="Hirotsugu" last="Ueshima">Hirotsugu Ueshima</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Ha Jee, Sun" sort="Ha Jee, Sun" uniqKey="Ha Jee S" first="Sun" last="Ha Jee">Sun Ha Jee</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Patel, Jeetesh V" sort="Patel, Jeetesh V" uniqKey="Patel J" first="Jeetesh V." last="Patel">Jeetesh V. 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